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.师资队伍.
  姓名郭媛   性别:女   民族:汉
  部门:有机化学与化学生物学学部    出生年月:1979-11-16
  籍贯:陕西泾阳   职称:教授
  邮箱:yuanorganic@163.com/ guoyuan@nwu.edu.cn   电话:18792766210(H)    
研究方向: 1、化学生物学:通过分子探针的构建与发现,实时、原位、定量探测生命活动; 2、有机合成化学:原子经济、绿色可持续和精准可控的有机合成方法研究; 3、精细有机化学品开发等。
简    介
  
  郭媛,女,1979年11月生,西北大学化学与材料科学学院教授、博士生导师。主讲化学学科本科核心课程《有机化学》。近年来主要从事有机荧光传感与分子识别、小分子与生物大分子相互作用、精细有机化学品开发等研究工作,现任EI期刊《精细化工》编委。
  主持国家自然科学基金项目3项(青年项目1项、面上项目2项)、省部级项目3项;发表科学研究论文60余篇,以第1或通讯作者在Chem. Sci.、Anal. Chem.、J. Mater. Chem. B.、Sen. Actuators B、Chem.-Asian J.、Ana. Chim. Acta、Dyes Pigm.、RSC Adv.、Tetrahedron Lett、 Asian J. Org. Chem.等国际知名学术期刊上发表SCI论文30余篇;申请国家发明专利9项,现已授权5项。作为主要完成人,分别于2005年、2010年获得陕西省科学技术壹等奖、叁等奖。2016年获得西安市青年科技人才奖。

  受教育、工作经历:

  2006/07-至今 西北大学化学与材料科学学院任教;

  2019/01-至今 法国国立奥尔良大学,特邀教授(invited professor);

  2012/10-2014/10 法国国家科研中心(CNRS)奥尔良ICOA研究所,博士后;

  2008/02-2011/02 空军军医大学,全军分子生物学重点实验室,博士后;

  2001/09-2006/06 西北大学,化学系有机化学专业,博士(硕-博连读);

  1997/09-2001/07 西北大学,化学系,本科。

  近期代表作:

  (1) D.L. Shi, S.Q. Chen, B. Dong, Y.H. Zhang, C.Q. Sheng, T.D. James, Y. Guo*. Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe. Chemical Science 2019, 10, 3715-3722. (Back cover story)

  (2) J.L, X.C. Yin, B. Li, X.K. Li, Y.J. Pan, J. Li, Y. Guo*. Spiropyran in situ switching: a real-time fluorescence strategy for tracking DNA G-quadruplexes in live cells. Analytical Chemistry 2019, 91, 5354-5361.

  (3) Q.M. Liu, A.Y. Li, X.K. Li, B. Li, Y.H. Zhang, J. Li, Y. Guo*. Selective visualization of live-cell mitochondrial thiophenols and their induced oxidative stress process by a rationally designed rhodol-based fluorescent probe. Sensors and Actuators B: Chemical 2019, 283, 820-830.

  (4) J. Li, X.K. Li, J.B. Jia, X. Chen, Y.J. Lv, Y. Guo*, J. Li*. A ratiometric near-infrared fluorescence strategy based on spiropyran in situ switching for tracking dynamic changes of live-cell lysosomal pH. Dyes and Pigments 2019, 166, 433-442.

  (5) J. Li, Y. Gao, H.R. Guo, X.K. Li, H.Y. Tang, J. Li, Y. Guo*. A novel colorimetric and ratiometric fluorescent probe for selective detection of bisulfite in real samples and living cells. Dyes and Pigments 2019, 163, 285-290.

  (6) Y.H. Zhang, L. Ma, C.C. Tang, S.N. Pan, D.L. Shi, S.J. Wang, M.Y. Li*, Y. Guo*. A highly sensitive and rapidly responding fluorescent probe based on a rhodol fluorophore for imaging endogenous hypochlorite in living mice. Journal of Materials Chemistry B 2018, 6, 725-731. (Front cover story)
   
  (7) H. Wang, D.L. Shi, J. Li, H.Y. Tang, Y. Guo*. A facile fluorescent probe with a large Stokes shift for sequentially detecting copper and sulfide in 100% aqueous solution and imaging them in living cells. Sensors and Actuators B: Chemical 2018, 256, 600-608.

  (8) H.Y. Tang, Y. Gao, B. Li, C.W. Li, Y. Guo*. Reaction-based colorimetric and ratiometric fluorescent probe for highly selective detection of silver ions. Sensors and Actuators B: Chemical 2018, 270, 562-569.

  (9) S.J. Wang, J. Li, Y. Gao, Y. Guo*. Highly selective and sensitive 2-(2’-hydroxyphenyl)benzothiazole-based turn-on fluorescent probes for detecting and imaging bisulfite in living cells. Asian Journal of Organic Chemistry 2018, 7, 563-569. (Invited) 

  (10) Y. Guo*, J. An, H.Y. Tang, M.J. Peng, F. Suzenet. Selective and “turn-off” fluorimetric detection of mercury(II)based on coumarinyldithiolane and coumarinyldithiane in aqueous solution. Materials Research Bulletin 2015, 63, 155-163.

  (11) Y.W. Duan, X.F. Yang*, Y.G. Zhong, Y. Guo*, Z. Li, H. Li. A ratiometric fluorescent probe for gasotransmitter hydrogen sulphide-based. Analytica Chimica Acta 2015, 859, 59-65.

  (12) M.J. Peng, X.F. Yang, B. Yin, Y. Guo*, F. Suzenet, D. En, J. Li, C.W. Li, Y.W. Duan. A novel hybrid coumarin-thiazole fluorescent sensor for selective detection of bisulfite anions in vivo and in real samples. Chemistry-An Asian Journal 2014, 9, 1817-1822.

  (13) H.M. Lv, X.F. Yang*, Y.G. Zhong, Y. Guo*, Z. Li, H. Li. Native chemical ligation combined with spirocyclization of benzopyrylium dyes for the ratiometric and selective fluorescence detection of cysteine and homocysteine. Analytical Chemistry 2014, 86, 1800-1807.

  (14) D. En, Y. Guo*, B.T. Chen, B. Dong, M.J. Peng. Coumarin-derived Fe3+ selective fluorescent turn-off chemosensors:synthesis, properties, and applications in living cells. RSC Advances 2014, 4, 248-253.

  (15) Y. Yan, D. En, Z. Zhuang, Y. Guo*, W.W. Liao*. Synthesis of densely functionalized a-methylene c-butyrolactones via an organocatalytic one-pot allylic-alkylation-cyclization reaction. Tetrahedron Letters 2014, 55, 479-482.

  (16) M.J. Peng, Y. Guo*, X.F. Yang, F. Suzenet, J. Li, C.W. Li, Y.W. Duan. Coumarin-hemicyanine conjugates as novel reaction-based sensors for cyanide detection: convenient synthesis and ICT mechanism. RSC Advances 2014, 4, 19077-19085.

  (17) Y.W. Duan, H.Y. Tang, Y. Guo*, Z.K. Song, M.J. Peng, Y. Yan. The synthesis and study of the fluorescent probe for sensing Cu2+ based on a novel coumarin Schiff-base. Chinese Chemical Letters 2014, 25, 1082-1086.

  (18) M.J. Peng, Y. Guo*, X.F. Yang*, L.Y. Wang, J. An. A highly selective ratiometric and colorimetric chemosensor for cyanide detection. Dyes and Pigments 2013, 98, 327-332.

  (19) Z.K. Song, B. Dong, G.J. Lei, M.J. Peng, Y. Guo*. Novel selective fluorescent probes for sensing Zn2+ ions based on acoumarin Schiff-base. Tetrahedron Letters 2013, 54, 4945-4949.

  申请专利9项,现已授权5项:

  (1) 郭媛,彭梦姣. 香豆素类衍生物及其制备方法和在检测氰根离子中的应用. 中国发明专利. 专利号:ZL 2012 1 0510755.7 已授权;

  (2) 郭媛,延永.羟基酪醇的合成方法. 中国发明专利. 专利号:ZL 2011 10357075.1. 已授权;

  (3) 史真,郭媛. 2,15-十六二酮的合成方法.中国发明专利.专利号:ZL 03 134386.4.已授权;

  (4) 郭媛,李剑利,史真. 龙癸醛的仿生合成方法.中国发明专利.专利号:ZL 200710018902.8. 已授权;

  (5) 李剑利,郭媛,史真. 卤代物羰基化反应方法.中国发明专利.专利号:ZL 200710018901.3. 已授权。

  科研获奖:

  2016年获西安市委组织部授予的“西安市青年科技人才奖”;

  2005年、2010年作为主要成员获“陕西省科学技术奖”一等奖、三等奖。

  教学情况:

主讲《有机化学》课程

  2009年西北大学第八届青年教师讲课比赛一等奖;

  2015年西北大学化材学院第五届青年教师讲课比赛特等奖;

  2011年西北大学化材学院第三届青年教师讲课比赛一等奖;

  2008年西北大学化材学院第一届青年教师讲课比赛一等奖。

  Prof. Yuan Guo, born in 1979, China, obtained her B. S. in 2001 and Ph. D. in 2006 from Department of Chemistry, Northwest University, China. She spent two years in France, as Post-doctoral research associate (2012–2014) at Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS. She served as Associate Professor of Chemistry (2009–2015) and Full Professor of Chemistry (2015-present) at Northwest University. Research interests: Biomimetic organic synthesis; Probe design and Chemosensing; Metal-catalyzed coupling reaction and its application in synthesis of heterocyclic compounds.

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