2019-11-13 18:39:22
院系概况
组织机构
师资队伍
党群工作
学生工作
校友会
 
 
登 录:
用户名
密 码
验证码
3793
所有教师

党政管理部

有机化学与化学生物学学部

无机化学与材料化学学部

分析化学学部

物理化学学部

高分子化学与物理学部

分析测试研究中心

国家级化学实验教学示范中心

分析科学研究所

 
谏言献策


书记信箱:
chemdzz@nwu.edu.cn

院长信箱:
chemdir@nwu.edu.cn

 
 
.师资队伍.
  姓名李剑利   性别:男   民族:汉
  部门:有机化学与化学生物学学部    出生年月:1973-02
  籍贯:陕西扶风   职称:教授
  邮箱:lijianli@nwu.edu.cn   电话:13363988385(H)    029-81535026(O)
研究方向: 有机化学,化学生物学
简    介
  李剑利,理学博士,教授、博士生导师,现任陕西省化学会副秘书长,陕西省高等教育学会副秘书长。曾任职西北大学化学与材料科学学院院长助理,西北大学国家级化学实验教学示范中心主任。1993年至1997年在西北大学化学系有机化学专业本科(基础人才培养基地班),获理学学士学位(导师朱兴才教授),留校任教;2002年至2007年在西北大学化学系有机化学专业硕-博连读,获理学博士学位(导师史真教授),研究方向仿生有机合成新反应及方法学研究;2007年至2011年在西北大学生命科学学院生物学博士后流动站合作研究(导师赵桂仿教授),主要从事复杂结构功能化合物(化学生物学光敏荧光探针)的设计合成与生物学应用研究;2012年1月-4月在法国斯特拉斯堡大学短期访学,从事生命体系光敏超分子识别研究;2015年入选“陕西省中青年科技创新领军人才支持计划”。

  主要研究方向:仿生有机化学、有机合成新反应和新方法、功能有机分子的设计合成及应用、有机能源化学研究。主持研究项目:国家自然科学基金面上项目(No.21572177;21272184;20972124)3项;中国博士后科学基金面上项目(No.20080441180)1项;陕西省科技统筹创新工程重大项目预研项目(No.2011K12-77)1项;陕西省自然科学基金重点项目(No.2015JZ003)1项、面上项目(No.2007B04)1项;陕北能源化工基地建设C1化学专项研究子课题1项、生态修复惠民工程子项目1项;陕西省教育厅自然科学基金专项(No.12JK0584;08JK456)2项;西安市科技攻关项目(No.CXY1429-6;CXY1123-1)2项;西北大学自然科学研究基金项目(No.05NW45)1项,以及陕西省教学改革研究重点项目(No.13BZ21)等多项教研项目。

  获奖情况摘要:国家教学成果奖二等奖2项;陕西省教学成果奖特等奖1项;陕西省科学技术奖壹等奖1项、叁等奖1项;陕西省高等学校科学技术奖壹等奖1项、贰等奖1项;2008-2011连续4届指导大学生国家级创新性实验计划项目获优秀;指导学生获“挑战杯”课外学术科技作品竞赛2011年校级、省级特等奖,2013年省级壹等奖、全国三等奖,个人荣获第十三届“挑战杯”全国大学生课外学术科技作品竞赛“优秀指导教师奖”。

  近年来,以第一作者或通讯作者先后在《Chemical Science》、《Organic Letters》、《Journal of Organic Chemistry》、《Analytical Chemistry》、《Inorganic Chemistry》、《Advanced Synthesis&Catalysis》、《Chemistry-An Asian Journal》、《Analytica Chimica Acta》、《Dalton Transactions》、《Scientific Reports》、《European Journal of Organic Chemistry》、《Sensors and Actuators B:Chemical》、《Dyes and Pigments》、《RSC Advances》、《Tetrahedron》、《Tetrahedron Letters》、《Synthesis》、《Journal of Luminescence》、《Chinese Chemical Letters》、《Chinese Journal of Chemistry》、《高等学校化学学报》等权威学术期刊发表研究论文多篇,论文引用次数已达800余次,国家授权发明专利15项,国家受理发明专利13项。

  近期代表性论文:

  45.Zhan Yan,Naixing Wang*,Xuewang Gao,Jianli Li*,Yuehua Wu,Tong Zhang,Shilu Chen*,Yalan Xing*.A copper(II)acetate mediated oxidative-coupling of styrenes and ethers through an unactivated C(sp3)-H bond functionalization.Advanced Synthesis&Catalysis,2019,361,1-6.

  44.Mengyao She#,Zhaohui Wang#,Tianyou Luo,Bing Yin,Ping Liu,Jing Liu,Fulin Chen*,Shengyong Zhang,Jianli Li*.Fluorescent probes guided by anew practical performance regulation strategy to monitor glutathione in living systems.Chemical Science,2018,9,8065-8070.(Back Cover)

  43.Jidong Zhang#,Mengyao She#,Jie Li,Cuiling Wang,Shen Wang,Ping Liu,Shengyong Zhang,Jianli Li*.Substituent effect on fluorescence signaling of the naphthalene carbohydrazone based chemosensor:Its implication in the detection of Zn(II)ions and secondary sensing PPi.Sensors and Actuators B:Chemical,2018,270,362-370.

  42.Shen Wang,Siyue Ma,Jidong Zhang,Mengyao She,Ping Liu,Shengyong Zhang,Jianli Li*.A highly sensitive and selective near-infrared fluorescent probe for imaging hydrazine in living tissues and mice.Sensors and Actuators B:Chemical,2018,261,418-424.

  41.Jidong Zhang,Zhan Yan,Shen Wang,Mengyao She,Zhao Zhang,Wangzhao Cai,Ping Liu,Jianli Li*.Water soluble chemosensor for Ca2+based on aggregation-induced emission characteristics and its fluorescence imaging in living cells.Dyes and Pigments,2018,150,112-120.

  40.Mengyao She#,Shaoping Wu#,Zhaohui Wang,Siyue Ma,Zheng Yang,Bing Yin,Ping Liu,Shengyong Zhang,and Jianli Li*.Exploration of congeneric Hg(II)-mediated chemosensors driven by S-Hg affinity,and their application in living system.Sensors and Actuators B:Chemical,2017,247,129-138.

  39.Siyue Ma#,Linyang Li#,Mengyao She,Yan Mo,Shengyong Zhang,Ping Liu,Jianli Li*.Synthesis and application of highly sensitive fluorescent probe for Hg2+regulated by sulfur.Chinese Chemical Letters,2017,28,2014-2018.

  38.Siyue Ma#,Yaqi Wang#,Mengyao She,Shen Wang,Zheng Yang,Ping Liu*,Shengyong Zhang,Jianli Li*.Design strategies and progress on xanthene based fluorescent probe for metal ions.Review in Analytical Chemistry,2017,36(2),20160024.

  37.Xilang Jin#,Shaoping Wu#,Mengyao She,Yifan Jia,Likai Hao,Bing Yin,Lanying Wang,Martin Obst,Yehua Shen,Yongmin Zhang,Jianli Li*.Novel fluorescein-based fluorescent probe for detecting H2S and its real applications in blood plasma and biological imaging.Analytical Chemistry,2016,88(22),11253-11260.

  36.Mengyao She#,Zheng Yang#,Likai Hao,Zhaohui Wang,Tianyou Luo,Martin Obst,Ping Liu,Yehua Shen,Shengyong Zhang,Jianli Li*.A novel approach to study the structure-property relationships and applications in living systems of modular Cu2+fluorescent probes.Scientific Reports,2016,6,28972.

  35.Zheng Yang,Mengyao She,Siyue Ma,Bing Yin,Ping Liu,Xiangrong Liu,Shunsheng Zhao,and Jianli Li*.Rhodamine based guanidinobenzimidazole functionalized fluorescent probe for tetravalent tin and its application in living cells imaging.Sensors and Actuators B:Chemical,2017,242,872-879.

  34.Yuelu Zhu,Cheng Li,Jidong Zhang,Mengyao She,Wei Sun,Kerou Wan,Yaqi Wang,Bin Yin,Ping Liu,Jianli Li*.A facile FeCl3/I2‑catalyzed aerobic oxidative coupling reaction:Synthesis of tetrasubstituted midazoles from amidines and chalcones.Organic Letters,2015,17(15),3872-3875.

  33.Hongmei Li,Cuiling Wang,Mengyao She,Yuelu Zhu,Jidong Zhang,Zheng Yang,Ping Liu,Yaoyu Wang,Jianli Li*.Two rhodamine lactam modulated lysosome-targetable fluorescence probes for sensitively and selectively monitoring subcellular organelle pH change.Analytica Chimica Acta,2015,900,97-102.

  32.Zheng Yang,Mengyao She,Bing Yin,Likai Hao,Martin Obst,Ping Liu*,Jianli Li*.Solvent-dependent turn-on probe for dual monitoring of Ag+and Zn2+in living biological samples.Analytica Chimica Acta,2015,868,53-59.

  31.Xilang Jin,Likai Hao,Mengyao She,Martin Obst,Andreas Kappler,Bing Yin,Ping Liu,Jianli Li*,Lanying Wang,Zhen Shi.Visualizing tributyltin(TBT)in bacterial aggregates by specific rhodamine-based fluorescent probes.Analytica Chimica Acta,2015,853,514-520.

  30.Siyue Ma,Zheng Yang,Mengyao She,Wei Sun,Bing Yin,Ping Liu,Shengyong Zhang,Jianli Li*.Design and synthesis of functionalized rhodamine based probes for specific intracellular fluorescence imaging of Fe3+.Dyes and Pigments,2015,115,120-126.

  29.Chen Li,Haixia Ge,Bing Yin,Mengyao She,Ping Liu*,Xiangdong Li,Jianli Li*.Novel 3,6-unsymmetrically disubstituted-1,2,4,5-tetrazines:S-induced one-pot synthesis,properties and theoretical study.RSC Advances,2015,5,12277-12286.

  28.Wei Sun#,Zhaohui Wang#,Mengyao She,Zheng Yang,Xilang Jin,Yaqi Wang,Zhen Shi,Jianli Li*.Study on the inclusion behavior and solid inclusion complex of 5-amino-6-methyl-2-benzimidazolone with cyclodextrins.Chinese Chemical Letters,2016,27,1077-1082.

  27.Wei Sun,Mengyao She,Zheng Yang,Yuelu Zhu,Siyue Ma,Zhen Shi,Jianli Li*.Study on the inclusion behaviour and solid inclusion complex of lomustine with cyclodextrins.Journal of Inclusion Phenomena and Macrocyclic Chemistry,2016,86,45-54.

  26.Chen Li,Bing Yin,Yifan Kang,Ping Liu*,Liang Chen,Yaoyu Wang,Jianli Li*.Mixed ligand CuIIN2O2 complexes:biomimetic synthesis,activities in vitro and biological models,theoretical calculations.Inorganic Chemistry,2014,53(24),13019-13030.

  25.Zheng Yang,Mengjia Wang,Mengyao She,Bing Yin,Yangyang Huang,Ping Liu,Jianli Li*,Shengyong Zhang.New aliphatic and aromatic dialdehyde bridged turn-on probes for hypochlorite detection in biological samples based on bis(fluorescein).Sensors and Actuators B:Chemical,2014,202,656-662.

  24.Cheng Li,Shujuan An,Yuelu Zhu,Jin Zhang,Yifan Kang,Ping Liu*,Yaoyu Wang,Jianli Li*.Copper-catalyzed intermolecular cyclization of nitriles and 2-aminobenzylamine for 3,4-dihydroquinazolines and quinazolines synthesis via cascade coupling and aerobic oxidation.RSC Advances,2014,4,49888-49891.

  23.Zheng Yang,Likai Hao,Bing Yin,Mengyao She,Martin Obst,Andreas Kappler,Jianli Li*.Six-membered spirocycle triggered probe for visualizing Hg2+in living cells and bacteria-EPS-mineral aggregates.Organic Letters,2013,15(17),4334-4337.

  22.Xiangnan Li,Cheng Li,Bing Yin,Cong Li,Ping Liu,Jianli Li*,Zhen Shi.DDQ-induced dehydrogenation on heterocycles for C-C double bond formation:synthesis of 2-thiazoles and 2-oxazoles.Chemistry-An Asian Journal,2013,8,1408-1411.

  21.Shujuan An,Bing Yin,Ping Liu,Xiangnan Li,Chen Li,Jianli Li*,Zhen Shi.Microwave-assisted cascade cycloaddition for C-N bond formation:An approach to the construction of 1,4,5,6-tetrahydropyrimidine and 2-imidazoline derivatives.Synthesis,2013,45,2525-2532.

  20.Yangyang Huang,Mengjia Wang,Zheng Yang,Mengyao She,Shu Wang,Ping Liu*,Jianli Li*,Zhen Shi.High efficient probes with Schiff base functional receptors for hypochlorite sensing under physiological conditions.Chinese Chemical Letters,2014,25,1077-1081.

  19.Yanning Shi,Xilang Jin,Yechen Hu,Shuli Wang,Jianli Li*,Zhen Shi.Synthesis and characterization of bis[2-(1Hbenzimidazol-2-yl)benzoato]nickel(II),and its use for preparation of dimethyl carbonate from methanol and CO2.Research on Chemical Intermediates,2014,40(3),1179-1186.

  18.Xilang Jin,Likai Hao,Yanling Hu,Mengyao She,Yanning Shi,Martin Obst,Jianli Li*,Zhen Shi.Two novel fluorescein-based fluorescent probes for hypochlorite and its real applications in tap water and biological imaging.Sensors and Actuators B:Chemical,2013,186,56-60.

  17.Zheng Yang,Mengyao She,Jin Zhang,Xiaoxiang Chen,Yangyang Huang,Hengyan Zhu,Ping Liu,Jianli Li*,Zhen Shi.Highly sensitive and selective rhodamine Schiff base“off-on”chemosensors for Cu2+imaging in living cells.Sensors and Actuators B:Chemical,2013,176,482-487.

  16.Mengyao She,Dawei Xiao,Bing Yin,Zheng Yang,Ping Liu,Jianli Li*,Zhen Shi.An efficiently cobalt-catalyzed carbonylative approach to phenylacetic acid derivatives.Tetrahedron,2013,69,7264-7268.

  15.Haixia Ge,Ping Liu,Xiangnan Li,Wei Sun,Jianli Li*,Bingqin Yang,Zhen Shi.S-Co(II)cascade catalysis:cyclocondensation of aromatic nitriles with alkamine.Tetrahedron,2013,69,6591-6597.

  14.Likai Hao*,#,Jianli Li#(共同一作),Andreas Kappler,Martin Obst.Mapping of Heavy Metal Ion Sorption to Cell-Extracellular Polymeric Substance-Mineral Aggregates by Using Metal-Selective Fluorescent Probes and Confocal Laser Scanning Microscopy.Applied and Environmental Microbiology,2013,79,6524-6534.

  13.Zheng Yang,Mengyao She,Bing Yin,Jihong Cui,Yuze Zhang,Wei Sun,Jianli Li*,Zhen Shi.Three rhodamine-based“off-on”chemosensors with high selectivity and sensitivity for Fe3+imaging in living cells.Journal of Organic Chemistry,2012,77(2),1143-1147.

  12.Xiangnan Li,Baoyue Zhou,Jin Zhang,Mengyao She,Shujuan An,Haixia Ge,Cong Li,Bing Yin,Jianli Li*,Zhen Shi.Solvent-free tandem synthesis of 2-thiazolines and 2-oxazolines catalyzed by acopper catalyst.European Journal of Organic Chemistry,2012,(8),1626-1632.

  11.Mengyao She,Zheng Yang,Bing Yin,Jin Zhang,Jia Gu,Wenting Yin,Jianli Li*,Guifang Zhao,Zhen Shi.A novel rhodamine-based fluorescent and colorimetric“off-on”chemosensor and investigation of the recognizing behavior towards Fe3+.Dyes and Pigments,2012,99(3),1337-1343.

  10.Wenting Yin,Hao Cui,Zheng Yang,Chen Li,Mengyao She,Bing Yin,Jianli Li*,Guifang Zhao,Zhen Shi.Facile synthesis and characterization of rhodamine-based colorimetric and“off-on”fluorescent chemosensor for Fe3+.Sensors and Actuators B:Chemical,2011,32(9),2046-2061.

  9.Xianglong Wu,Xilang Jin,Yunxia Wang,Qibing Mei,Jianli Li*,Zhen Shi*.Synthesis and spectral properties of novel chlorinated pH fluorescent probes.Journal of Luminescence,2011,131,776-780.

  8.Jin Zhang,Xiao Wang,Meipan Yang,Kerou Wan,Bing Yin,Yunxia Wang,Jianli Li*,Zhen Shi.Copper-catalyzed synthesis of 2-imidazolines and their N-hydroxyethyl derivatives under various conditions.Tetrahedron Letters,2011,157(2),675-680.

  7.Bin Zhang,Jianli Li*,Wei Chen,Yunxia Wang,Zhen Shi.Synthesis,crystal structure of Co(II)(6-methoxybenzothiazole-2-carboxylate)2(DMF)2 and its application to carbonylation of benzyl chloride.Chinese Journal of Chemistry,2010,28(1),111-114.

  6.Dawei Xiao,Bin Zhang,Jianli Li*,Zhen Shi.Synthesis and characterization of anew ligand 2-(4,5-dihydro-2-thiazolyl)-6-methoxylbenzothiazole and its dinuclear Co(II)complex.Chinese Journal of Structural Chemistry,2010,29(11),1712-1716.

  5.黄阳阳,王梦嘉,厍梦尧,杨征,刘萍,李剑利*,史真.基于氧杂蒽结构可控官能化的荧光探针研究新进展,有机化学,2014,34(1),1-25.(本期封面文章)

  4.周葆悦,张金,李向南,厍梦尧,张劲,李剑利*,史真.2-咪唑啉类化合物的合成及应用研究新进展,有机化学,2013,33(3),423-435.(本期封面文章)

  3.李晨,杨征,厍梦尧,尹文婷,李剑利*,赵桂仿,史真.超氧化物歧化酶化学模拟的新进展,高等学校化学学报,2011,32(9),2046-2061.

  2.李娜,刘美玲,尹文婷,杨征,李剑利*,史真.罗丹明基“OFF-ON”型荧光探针研究的一些新进展,有机化学,2011,31(1),39-53.

  1.李剑利,尹文婷,张金,郭媛,武祥龙,白银娟,史真*.环己基甲酮类化合物的仿生合成方法研究,高等学校化学学报,2008,29(1),100-103.

  (*通讯作者;#共同第一作者)

  

返回
 
 
化学与材料科学学院 地址:陕西省西安郭杜教育产业园区学府大道1号 电话:029-81535026 邮件:chembgs@nwu.edu.cn