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有机化学与化学生物学学部

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书记信箱:
chemdzz@nwu.edu.cn

院长信箱:
chemdir@nwu.edu.cn

 
 
.师资队伍.
  姓名王兰英   性别:女   民族:汉
  部门:有机化学与化学生物学学部    出生年月:1962-02-01
  籍贯:山西、芮城   职称:教授
  邮箱:wanglany@nwu.edu.cn   电话:    029-81535026(O)
研究方向: ① 多功能菁染料的绿色设计合成、应用及理论研究;② 靶向生物分子荧光探针研究;③ 有机合成中间体的新合成方法研究。
简    介
  王兰英,教授/博导,女,1962年2月生。1984年7月毕业于山西大学化学系,获理学学士学位。1988年9月至1991年7月在西北大学化学系有机化学专业攻读理学硕士学位。2005年12月工学博士毕业于西北工业大学材料学院。1991年至今在西北大学化学与材料科学学院从事有机化学教学与科研工作。是西北大学化学与材料科学学院学科平台课程《有机化学》主持人,多年来一直担任化材学院基地班、本科班《有机化学》课程主讲。主持教育部国家理科基地创建名牌课程《有机化学》建设项目、陕西省精品课程《有机化学》建设项目,是西北大学校重点课程建设项目《有机化学》的主要完成人,多次在讲课比赛、教学质量优秀奖评比中获奖。“紧扣教学质量提高及学生创新能力培养,建设有机化学精品课程”获西北大学教学成果二等奖。主要研究方向:① 多功能菁染料的绿色设计合成、应用及理论研究;② 靶向生物分子荧光探针研究;③ 有机合成中间体的新合成方法研究。主持陕西省自然科学基金项目“菁染料的绿色合成及其应用研究”、“含菁发色团环糊精衍生物的合成及功能分子材料的组装”,陕西省科学技术研究发展计划项目“红外区强吸收的多核光敏染料/硅光伏材料的开发研究”、“菁类光化学传感材料的研发及其在癌细胞诊断中的应用”,陕西省教委专项科学研究基金项目“硅碳双键化合物的合成及其性能的研究”、“高密度光存储材料—菁染料的合成及其应用”、“新型生物大分子荧光探针的合成及其应用”和“用于活细胞内成像检测核酸的缩氨酸-二甲川菁结合物荧光探针的合成与应用”等多项研究;参加国家自然基金项目“金属-有机骨架结构导向多功能化定向调控的高性能电化学传感研究”、总装备部预研项目“C/C热结构复合材料研究”和“酞菁催化锂/亚硫酰氯储备电池技术研究”。在《高等学校化学学报》《化学学报》《中国化学》《Dyes and Pigments》《Journal of Organic Chemistry》《Journal of Photochemistry & Photobiology, B Biology》《Organic Letters》等国内外权威期刊发表学术论文80余篇。研究成果获2006年度陕西省科学技术贰等奖(第一完成人),陕西省高等学校科学技术壹等奖(第一完成人)。获2004年度陕西省科学技术壹等奖(第四完成人),陕西省高等学校科学技术壹等奖(第四完成人)。

近期代表性论文:
[1]Approach to introducing substituent on the dipole conjugate chain: the D−π−A methine chain electrophilic substitution. Organic Letters,2018, 20 (1): 60-63.

[2]Synthesis and effect on SMMC-7721 cells of new benzo[c, d]indole rhodanine complex merocyanines as PDT photosensitizers. Tetrahedron, 2017, 73 (24): 3355-3362.

[3]Norcyanine dyes with benzo[c,d]indolium moiety: spectral sensitivity with pH change for fluorescence pH imaging in living cells. Journal of Photochemistry & Photobiology, B Biology, 2017, 166: 239-245.

[4] Solvent-dependent ratiometric fluorescent merocyanine dyes: Spectral properties, interaction with BSA as well as biological applications. Dyes and Pigments, 2016, 129: 163-173.

[5]Non-Planar Monocyanines:Meso-Substituted Thiazole Orange with High Photostability and their Synthetic Strategy as well as Cells Association Study. Journal of Organic Chemistry, 2016, 81 (15): 6303-6313.

[6] Synthesis, crystal structures, spectral properties of dimethine cyanine dyes with N-benzyl indole nucleus as well as their interaction with biomolecules and living cells. RSC Advances,2015, 5 (6): 4681-4692.

[7]吲哚二甲川菁的合成、晶体结构、光谱性质及其生物应用, 高等学校化学学报,2015, 36 (10): 1924-1932.

[8]Synthesis, spectral properties of double D-π-A mono cyanines as well as preparation of near infrared silicon-based materials. RSC Advances,2015, 5 (79): 64626-64632.

[9]Synthesis of cell-permeant dimethine cyanine dyes as fluorescent probes for living cell imaging and flow cytometry, Dyes and Pigments, 2014, 100 (1): 232-240.

[10]An OFF-ON-OFF Type of pH Fluorescent Sensor: Benzo[c,d]indole-based Dimethine Cyanine Dye--Synthesis, Spectral Properties and Density Functional Theory Studies. Journal of Luminescence, 2014, 154: 124–130.

[11]Synthesis, Spectral Properties of Cyanine Dye-β-Cyclodextrin and Their Application as the Supramolecular Host with Spectroscopic Probe. Dyes and Pigments, 2013, 96 (1): 180-188.

[12]Efficient One-Pot Three-Component Synthesis of Monomethine Cyanine Dyes with Quinoline Nucleus and Their Spectral Properties. Bulletin of the Korean Chemical Society,2013,34(2):489-494.

[13]One trinucleus dimethine cyanine dye: experimental and theoretical studies on molecular structure as well as absorption and fluorescence properties. Journal of Molecular Structure, 2013, 1039: 84-93.

[14]Synthesis, crystal structure, spectral and thermodynamic properties of one benzoindole pentamethine cyanine dye. Journal of the Chinese Chemical Society,2013, 60 (5): 503-510.

[15]The experimental and DFT studies of 1, 3-dimethyl-2-[4-chloro-styryl]- benzimidazolium iodide. Journal of Molecular Structure, 2012, 1007 (1-3): 275-281.

[16]Synthesis, Spectral Properties of Rhodanine Complex Merocyanine Dyes as Well as Their Effect on K562 Leukemia Cells, Dyes and Pigments, 2012, 93 (3): 1481-1487.

[17]The synthesis, spectroscopic properties and crystal structures of some rhodanine merocyanine dyes for optical recording with a blue diode laser, Dyes and Pigments, 2011, 91 (3): 370-377.

[18]Synthesis, absorption and fluorescence spectral characteristics of trinucleus dimethine cyanine dyes as fluorescent probes for DNA detection. Journal of the Brazilian Chemical Society, 2011, 22 (1): 73-79.

[19]Synthesis and spectral properties of novel water-soluble indocyanine dyes as fluorescent dyes for proteins detection, Chinese Journal of Chemistry, 2011, 29 (3): 493-498.

[20]Synthesis and structural studies of 4-[(5-methoxy-1H-indole-3-yl) -methylene]-3-methyl-isoxazole-5-one by X-ray crystallography, NMR spectroscopy, and DFT calculations. Journal of Molecular Structure, 2011, 994 (1-3): 371-378.

[21]The experimental and theoretical study of crystal structure, IR, 1H NMR and UV-vis of 2-styryl-β-naphthathiazole dye. Journal of Molecular Structure, 2010, 977 (1-3): 39-44.

[22]The absorption,emission spectra as well as ground and excited states calculations of some dimethine cyanine dyes.Journal of Molecular Structure:THEOCHEM,2009,906(1-3):50-55.

[23]Monomethine cyanine dyes with an indole nucleus:Microwave-assisted solvent-free synthesis,spectral properties and theoretical studies.Dyes and Pigments,2009,82(3):409-415.

[24]Study on thermodynamics of three kinds of benzindocarbocyanine dyes in aqueous methanol solution.Bulletin of the Korean Chemical Society,2009,30(3):556-560.

[25]Microwave-assisted solvent-free synthesis and spectral properties of some dimethine cyanine dyes as fluorescent dyes for DNA detection.Dyes and Pigments,2008,79(2):205-209.

[26]X-ray and DFT studies of the structure and spectral property of 2-[2-(4-dimethylaminophenyl)ethenyl]-1-methyl-pyridinium iodide.Journal of Molecular Structure,2008,881(1-3):117-122.

[27]Theoretical study on the structures and absorption properties of styryl dyes with quinoline nucleus.Dyes and Pigments,2007,72(3):357-362.

[28]Synthesis and Properties of Novel Hemicyanine Dye-β-Cyclodextrin.Chinese Journal of Chemistry,2007,25(8):1192-1195.

[29]Microwave-assisted solvent-free synthesis of some dimethine cyanine dyes,spectral properties and TD-DFT/PCM calculations.Bulletin of the Korean Chemical Society,2007,28(12):2382-2388.

[30]Investigation of the Structures and Absorption Spectra for Some Hemicyanine Dyes with Pyridine Nucleus by TD-DFT/PCM Approach.Journal of Molecular Structure THEOCHEM,2006,778(1-3):15-20.

[31]Microwave-assisted solvent-free synthesis of some hemicyanine dyes.Dyes and Pigments,2004,62(1):21-25.

[32]Microwave-assisted solvent-free synthesis of some styryl dyes with benzimidazole nucleus.Synthetic Communications,2004,34(12):2245-2252.

[33]苯并吲哚半菁、二甲川菁染料的微波合成、光谱性能及与生物分子的相互作用. 有机化学, 2012, 32 (3): 567-573.

[34]苯乙烯基-β-萘噻唑染料的结构与电子光谱的含时密度泛函研究.化学学报,2005,63(1):39-43.

[35]以甲苯为前驱体化学液气相沉积法制备碳/碳复合材料.高等学校化学学报,2005,26(6):1002-1005.

[36]烯基取代的甲酸态四氢叶酸辅酶模型的合成及其碳单元转移反应.高等学校化学学报,2003,24(2):265-269.

[37]Solvent-free Rapid Synthesis of Styryl Dyes with Benzimidazole Nucleus Using Microwave Irradiation.Chinese Chemical Letters,2003,14(11),1116-1118.

[38]吲哚菁染料的研究进展.有机化学,2006,26(4):442-453.
   

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化学与材料科学学院 地址:陕西省西安郭杜教育产业园区学府大道1号 电话:029-81535026 邮件:chembgs@nwu.edu.cn