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有机化学与化学生物学学部

无机化学与材料化学学部

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国家级化学实验教学示范中心

分析科学研究所

 
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书记信箱:
chemdzz@nwu.edu.cn

院长信箱:
chemdir@nwu.edu.cn

 
 
.师资队伍.
  姓名和媛   性别:女   民族:汉
  部门:有机化学与化学生物学学部    出生年月:1984-03
  籍贯:陕西西安   职称:副教授
  邮箱:yuanhe@nwu.edu.cn
研究方向: 酶催化反应机理及调控;纳米生物学;化学糖生物学;蛋白质晶体结构解析;疾病快速检测;等温滴定微量热;小分子抑制剂开发;天然活性产物资源化;
简    介
2013-至今,西北大学化学与材料学院,副教授,陕西省百人计划特聘专家
2011-2013,加拿大 Simon Fraser University(David Vocadlo 教授实验室)/美国斯克利普斯研究所(The Scripps Research Institute; Jim Paulson 教授实验室)博士后
2007-2011,英国约克大学(the University of York) 博士 (化学)(Gideon Davies 院士)
2006-2007, 英国约克大学(the University of York) 硕士(功能基因组学专业)
2002-2006,西北大学理学学士

和媛副教授课题组主要从事疾病相关靶酶反应机理及调控研究。主要研究手段包括:X-射线晶体衍射、酶学、等温滴定微量热(ITC)、ELISA、流式细胞术、生物芯片等。研究成果发表在包括 JACS, Nature Structural & Molecular Biology, Nature Chemical Biology 等在内的著名国际期刊。该研究小组现招收化学生物学、有机化学、材料工程等相关专业的硕士研究生开展以下课题研究:

1.微量热技术用于酶活力表征的方法研究
2.病原微生物的化学糖生物学研究与药物开发
3.纳米生物学

发表论文:

Y. Zhang, J. E. Lei, Y. He*, J. Yang, W. Wang, J. Xu, H. Fan, G. Jing, C. Zhang, Y. Jin, Y. Lin, A. Wasey, Label-Free Visualization of Carbapenemase Activity in Living Bacteria, Angew Chem Int Ed Engl, 2018.

Q. Wang, Y. He*, R. Lu, W. M. Wang, K. W. Yang, H. M. Fan, Y. Jin, G. M. Blackburn, Thermokinetic profile of NDM-1 and its inhibition by small carboxylic acids, Biosci Rep, 2018, 38(2).

和媛*,张桢,谢钢,大学化学类专业英语听说课程教学的实践与改进,大学化学,2018.

H. Zhang, X. L. Liu, Y. F. Zhang, F. Gao, G. L. Li, Y. He, M. L. Peng, H. M. Fan, Magnetic nanoparticles based cancer therapy: current status and applications, Sci China Life Sci, 2018, 61(4): 400-414.

Y. Xiang, C. Chen, W. M. Wang, L. W. Xu, K. W. Yang, P. Oelschlaeger, Y. He*, Rhodanine as a Potent Scaffold for the Development of Broad-Spectrum Metallo-beta-lactamase Inhibitors, ACS Med Chem Lett, 2018, 9(4): 359-364.

Wen-Jing Wang, Qian Wang, Ye Zhang, Rui Lu, Yi-Lin Zhang, Ke-Wu Yang, Jin-E Lei, Yuan He*, Characterization of beta-lactamase activity using isothermal titration calorimetry, Biochim Biophys Acta, 2017, 1861(8): 2031-2038.

G. Li, P. Ma, Y. He, Y. Zhang, Y. Luo, C. Zhang, H. Fan, Enzyme-Nanowire Mesocrystal Hybrid Materials with an Extremely High Biocatalytic Activity, Nano Lett, 2018.

Matthew S Macauley, Norihito Kawasaki, Wenjie Peng, Shui-Hua Wang, Yuan He, Britni M Arlian, Ryan McBride, Reiji Kannagi, Kay-Hooi Khoo, James C Paulson, Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man, J Biol Chem, 2015, 290(50): 30066-30077.

Yuan He, Christian Roth, Johan P Turkenburg, Gideon J Davies, Three-dimensional structure of a Streptomyces sviceus GNAT acetyltransferase with similarity to the C-terminal domain of the human GH84 O-GlcNAcase, Acta Crystallogr D Biol Crystallogr, 2014, 70(Pt 1): 186-195.

Cory D Rillahan, Matthew S Macauley, Erik Schwartz, Yuan He, Ryan McBride, Britni M Arlian, Janani Rangarajan, Valery V Fokin, James C Paulson, Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas, Chem Sci, 2014, 5(6): 2398-2406.

John F Darby, Jens Landstrom, Christian Roth, Yuan He, Gideon J Davies, Roderick E Hubbard, Discovery of selective small-molecule activators of a bacterial glycoside hydrolase, Angew Chem Int Ed Engl, 2014, 53(49): 13419-13423.

Matthew S Macauley, Jefferson Chan, Wesley F Zandberg, Yuan He, Garrett E Whitworth, Keith A Stubbs, Scott A Yuzwa, Andrew J Bennet, Ajit Varki, Gideon J Davies, David J Vocadlo, Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular beta-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of beta-O-linked beta-N-acetylglucosaminidase, J Biol Chem, 2012, 287(34): 28882-28897.

Yuan He, Abigail K Bubb, Keith A Stubbs, Tracey M Gloster, Gideon J Davies, Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses, Amino Acids, 2011, 40(3): 829-839.

Yuan He, Matthew S Macauley, Keith A Stubbs, David J Vocadlo, Gideon J Davies, Visualizing the reaction coordinate of an O-GlcNAc hydrolase, J Am Chem Soc, 2010, 132(6): 1807-1809.

Matthew S Macauley, Yuan He, Tracey M Gloster, Keith A Stubbs, Gideon J Davies, David J Vocadlo, Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes, Chem Biol, 2010, 17(9): 937-948.

Carlos Martinez-Fleites, Yuan He, Gideon J Davies, Structural analyses of enzymes involved in the O-GlcNAc modification, Biochim Biophys Acta, 2010, 1800(2): 122-133.

Misty D Balcewich, Keith A Stubbs, Yuan He, Terrence W James, Gideon J Davies, David J Vocadlo, Brian L Mark, Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ, Protein Sci, 2009, 18(7): 1541-1551.

Yuan He, Carlos Martinez-Fleites, Abigail Bubb, Tracey M Gloster, Gideon J Davies, Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase, Carbohydr Res, 2009, 344(5): 627-631.

Filipa Marcelo, Yuan He, Scott A Yuzwa, Lidia Nieto, Jesus Jimenez-Barbero, Matthieu Sollogoub, David J Vocadlo, Gideon D Davies, Yves Bleriot, Molecular basis for inhibition of GH84 glycoside hydrolases by substituted azepanes: conformational flexibility enables probing of substrate distortion, J Am Chem Soc, 2009, 131(15): 5390-5392.

Carlos Martinez-Fleites, Matthew S Macauley, Yuan He, David L Shen, David J Vocadlo, Gideon J Davies, Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation, Nat Struct Mol Biol, 2008, 15(7): 764-765.

Scott A Yuzwa, Matthew S Macauley, Julia E Heinonen, Xiaoyang Shan, Rebecca J Dennis, Yuan He, Garrett E Whitworth, Keith A Stubbs, Ernest J McEachern, Gideon J Davies, David J Vocadlo, A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo, Nat Chem Biol, 2008, 4(8): 483-490.

Zhong-Fu Wang, Yuan He, Lin-Juan Huang, An alternative method for the rapid synthesis of partially O-methylated alditol acetate standards for GC-MS analysis of carbohydrates, Carbohydr Res, 2007, 342(14): 2149-2151.

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