2019-08-20 03:20:05
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有机化学与化学生物学学部

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书记信箱:
chemdzz@nwu.edu.cn

院长信箱:
chemdir@nwu.edu.cn

 
 
.师资队伍.
  姓名张健健   性别:男   民族:汉
  部门:分析化学学部 
  籍贯:江苏启东   职称:副教授
  邮箱:zhangjj@nwu.edu.cn
研究方向: 1、有机小分子近红外荧光探针的合成与设计 2、激活型分子探针在细胞和动物活体的光声成像分析中的应用 3、设计靶向型诊疗探针在肿瘤早期诊断与治疗评价中的应用
简    介
  张健健,博士,特评副教授,硕导。2010年本科毕业于中国矿业大学化学工程与工艺系,同年被保送到兰州大学有机化学专业,导师彭羽教授。并以硕博连读形式攻读分析化学博士学位,导师张海霞教授。2016年3月至2017年8月在新加坡南洋理工大学浦侃裔副教授处做博士后研究。2017年8月至今在西北大学化学与材料科学学院任教。迄今为止在Advanced Materials,Analytical Chemistry,Chemical Communications,Organic&Biomolecular Chemistry等国际著名期刊及分析化学类权威期刊以第一作者身份发表7篇。2017年获中国分析测试协会科学技术奖三等奖(第二名)。2018年入选陕西省特聘专家(青年千人项目)。

  欢迎对本课题组感兴趣的同学报考!

  联系地址:化学与材料科学学院532室15829055232

  入职后发表文章

  25.Jianjian Zhang,*Penghui Cheng,Kanyi Pu,*Recent Advances of Molecular Optical Probes in Imaging ofβ-Galactosidase.Bioconjugate Chemistry,2019,July 8.Accepted.(Invited Review)

  24.Yuan Liu,Dandan Rena Jianjian Zhanga,Hua Li,Xiao-Feng Yang*A fluorescent probe for hydrazine based on anewly developed 1-indanonefused coumarin scaffold.Dyes and Pigments 2019,162,112–119.

  23.Biliu Wu,Jiajun Yang,Jianjian Zhang,Zheng Li,Hua Li,Xiao-Feng Yang*A ratiometric fluorescent probe for the detection of endogenous hydroxyl radicals in living cells.Talanta 2019,196,317–324.

  22.Shengrui Zhang,Qin Wang,Xiawei Liu,Jianjian Zhang,Xiao-Feng Yang,*Zheng Li and Hua Li,*Sensitive and Selective Fluorescent Probe for Selenol in Living Cells Designed via apKa Shift Strategy.Anal.Chem.,2018,90,4119-4125.

  21.Jianjian Zhang,Xu Zhen,Jianfeng Zeng,Kanyi Pu,*A Dual-modal Molecular Probe for Near-infrared Fluorescence and Photoacoustic Imaging of Peroxynitrite.Analytical Chemistry,2018,90,9301-9307.

  20.Penghui Cheng,Jianjian Zhang,Jiaguo Huang,Qingqing Miao,Chenjie Xu,Kanyi Pu.*Near-infrared fluorescence probes detect reactive oxygen species for keloid diagnosis.Chemical Science,2018,9,6340-6347.[2018 Chemical Science HOT Article Collection].

  19.Xiaoqian Ma,Xiaoxiao Shi,Shuang Bai,Jianjian Zhang,Meili Hou,Tian Zhang,Bao-sheng Li,Peng Xue,Yuejun Kang and Zhigang Xu.*Water-soluble Fluorescent Unimolecular Micelles:Ultra-small Size,Tunable Fluorescence Emission from Visible to NIR Region and Enhanced Biocompatibility for In Vitro and In Vivo Bioimaging.Chemical Communications,2018,54,6252-6255.

  18.Xu Zhen,Jianjian Zhang,Jiaguo Huang,Chen Xie,Qingqing Miao,Kanyi Pu.*Macrotheranostic probe with disease‐activated near‐infrared fluorescence,photoacoustic and photothermal signals for imaging‐guided therapy.Angewandte Chemie International Edition,2018,57,7804–7808.

  17.Qingqing Miao,David Yeo,Christian Wiraja,Jianjian Zhang,Xiaoyu Ning,Chenjie Xu,Kanyi Pu.*Near-infrared fluorescent molecular probe for sensitive imaging of keloid.Angewandte Chemie International Edition,2018,57,1256–1260.

  入职前发表文章

  16.Jianjian Zhang,Xu Zhen,Paul Kumar Upputuri,Manojit Pramanik,Peng Chen,Kanyi Pu.*Activatable photoacoustic nanoprobes for in vivo ratiometric imaging of peroxynitrite.Advanced Materials,2017,29,1604764.[Cover]

  15.Jianxi Wang,Cheng Zhou,Wei Liu,Jianjian Zhang,Xinyue Zhu,Xiaoyan Liu,Qin Wang and Haixia Zhang,*A near-infrared fluorescent probe based on chloroacetate modified naphthofluorescein for selectively detecting cysteine/homocysteine and its application in living cells.Photochemical&Photobiological Sciences,2016,15,1393-1399.

  14.Jianjian Zhang,Chuwen Li,Rui Zhang,Fengyuan Zhang,Wei Liu,Xiaoyan Liu,Simon Ming-Yuen Lee,Haixia Zhang,*A Phosphinate-Based Near-Infrared Fluorescence Probe for Imaging the Superoxide Radical Anion in In Vitro and In Vivo.Chem.Commun.,2016,52,2679-2682.(Front Cover)

  13.Jianjian Zhang,Lulu Ning,Jiting Liu,Jianxi Wang,Bianfei Yu,Xiaoyan Liu,Xiaojun Yao,Zi-Ping Zhang,Haixia Zhang,*Naked-Eye and Near-Infrared Fluorescence Probe for Hydrazine and Its Applications in In Vitro and In Vivo Bioimaging.Anal.Chem.,2015,87,9101-9107.

  12.Jianjian Zhang,Jianxi Wang,Jiting Liu,Lulu Ning,Xinyue Zhu,Bianfei Yu,Xiaoyan Liu,Xiaojun Yao,Haixia Zhang,*Near-Infrared and Naked-Eye Fluorescence Probe for Direct and Highly Selective Detection of Cysteine and Its Application in Living Cells.Anal.Chem.,2015,87,4856-4863.

  11.Jianjian Zhang,Bianfei Yu,Lulu Ning,Xinyue Zhu,Jianxi Wang,Zhenjie Chen,Xiaoyan Liu,Xiaojun Yao,Xiaoyu Zhang,Haixia Zhang,*A Near-Infrared Fluorescence Probe for Thiols Based on Analyte-Specific Cleavage of Carbamate and Its Application in Bioimaging.Eur.J.Org.Chem.,2015,1711-1718.

  10.Jianjian Zhang,Changsong Yan,Yu Peng,*Zhenbiao Luo,Xiaobo Xu,Yawen Wang,Total synthesis of(±)-sacidumlignans Dand Athrough Ueno-Stork radical cyclization reaction.Org.Biomol.Chem.,2013,11,2498-2513.

  9.Xinyue Zhu,Yan Li,Wenyan Zan,Jianjian Zhang,Zhenjie Chen,Xiaoyan Liu,Fengchao Qi,Xiaojun Yao,Xiaoyu Zhang,Haixia Zhang,*A two-photon off-on fluorescence probe for imaging thiols in live cells and tissues.Photochem.Photobiol.Sci.,2016,15,412-419.

  8.Xinyue Zhu,Jianxi Wang,Jianjian Zhang,Zhenjie Chen,Haixia Zhang,*Xiaoyu Zhang,Imaging of Fluoride Ion in Living Cells and Tissues with aTwo-Photon Ratiometric Fluorescence Probe,Sensors,2015,15,1611-1622.

  7.Xinyue Zhu,Hong Gao,Wenyan Zan,Yan Li,Jianjian Zhang,Xiaoyan Liu,Xuan Wei,Fengchao Qi,Xiaojun Yao,Haixia Zhang,*A rational designed thiols fluorescence probe:the positional isomer in PET.Tetrahedron,2016,72,2048-2056.

  6.Yan Li,Yanxin Qiu,Jianjian Zhang,Xinyue Zhu,Bin Zhu,Xiaoyan Liu,Xiaoyu Zhang,Haixia Zhang,*Naphthalimide derived fluorescent probes with turn-on response for Au3+and the application for biological visualization,Biosens.Bioelectron.,2016,83,334-338.

  5.Jianxi Wang,Cheng Zhou,Jianjian Zhang,Xinyue Zhu,Xiaoyan Liu,Qin Wang,Haixia Zhang,*A new fluorescence turn-on probe for biothiols based on photoinduced electron transfer and its application in living cells,Spectrochim Acta A,2016,166,31-37.

  4.Long Luo,Jianjian Zhang,Weijian Ling,Yongliang Shao,Yawen Wang,Yu Peng,*Unified Synthesis of(-)-Folicanthine and(-)-Ditryptophenaline Enabled by aRoom Temperature Nickel-Mediated Reductive Dimerization.Synthesis,2014,46,1908-1916.

  3.Yu Peng,*Zhenbiao Luo,Jianjian Zhang,long Luo,Yawen Wang,Collective synthesis of several 2,7'-cyclolignans and their correlation by chemical transformations.Org.Biomol.Chem.,2013,11,7574-7586.

  2.Yu Peng,*Long Luo,Changsong Yan,Jianjian Zhang,Yawen Wang,Ni-Catalyzed Reductive Homocoupling of Unactivated Alkyl Bromides at Room Temperature and Its Synthetic Application.J.Org.Chem.,2013,78,10960-10967.

  1.Xiaobo Xu,Jian Liu,Jianjian Zhang,Yawen Wang,Yu Peng,*Nickel-Mediated Inter-and Intramolecular C-S Coupling of Thiols and Thioacetates with Aryl Iodides at Room Temperature.Org.Lett.,2013,15,550-553.

  

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化学与材料科学学院 地址:陕西省西安郭杜教育产业园区学府大道1号 电话:029-81535026 邮件:chembgs@nwu.edu.cn